Non-Rapid Eye Movement Sleep Arousal (NREM Disorder in Adults

ICD-10 Codes:

Sleepwalking type: F51.3

Sleep terror type: F51.4

Non-rapid eye movement (NREM) sleep arousal disorders are part of a cluster of diagnoses called the sleep-wake disorders. Sleep-wake disorders are a group of psychiatric conditions that include:

  • Insomnia Disorder
  • Hypersomnolence Disorder
  • Non-Rapid Eye Movement Sleep Arousal Disorders
  • Nightmare Disorder
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These disorders are broadly characterized by disruptions in sleep and wakefulness. Individuals with insomnia disorder have frequent difficulty falling asleep or staying asleep. Individuals with hypersomnolence disorder feel excessively sleepy during the day, despite obtaining what for most people would be a full night of sleep. Individuals with parasomnias such as non-rapid eye movement sleep arousal disorders and nightmare disorder experience unusual behaviors while sleeping, such as sleep walking, or vivid and disturbing dreams or night terrors.

Some sleep-wake disorders, including insomnia disorder and hypersomnolence disorder, are associated with disturbances in the amount of time the individual spends asleep (too much or too little) or the times at which the individual sleeps (often outside of the desired sleeping window). Other disorders, such as the parasomnias, are not associated with disturbances in the quantity or timing of sleep per se, but are instead associated with behavioral disturbances during sleep or frequent highly distressing dreams.

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What is Non-Rapid Eye Movement Sleep Arousal Disorder?

NREM sleep arousal disorders, also called parasomnias, affect approximately 2 - 4% of adults.

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Although parasomnias can take several forms, an individual is typically diagnosed with a NREM sleep arousal disorder when he or she experiences one of the following on a regular basis:

  • Sleepwalking, in which the individual rises from bed and moves around while still asleep. Individuals who are sleepwalking typically cannot communicate and are awakened only with significant difficulty.
  • Night terrors, in which the individual awakes abruptly from sleep in a panicked, intensely fearful state.

Individuals who experience sleepwalking or night terrors remember little or nothing of these episodes, including any dreams that may have occurred.

Occasional parasomnias are fairly common, occurring in approximately 30% of adults at some point in their lives. Therefore, NREM sleep arousal disorders are diagnosed only when the parasomnias occur repeatedly and cause clinically significant distress or impairment.

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Understanding Non-Rapid Eye Movement Sleep Arousal Disorder

NREM sleep arousal disorders can range in severity from mild to severe. In severe cases, NREM sleep arousal disorders can adversely impact relationships with significant others and lead to medicolegal consequences, particularly if the individual engages in behaviors that may put others at risk (e.g., sleep-related violent or sexual behavior; driving while asleep).

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NREM sleep arousal disorders can also lead to sleep avoidance or impaired concentration or efficiency during the day. NREM sleep arousal disorders often occur in isolation, but can co-occur with other psychological disorders, including major depressive disorder and obsessive-compulsive disorder.

NREM sleep arousal disorders are thought to stem from abnormalities in sleep architecture, including deeper sleep, greater occurrence and fragmentation of slow-wave sleep, and alterations in delta activity during sleep, which give rise to the disorder. Parasomnias are thought to increase in frequency following the consumption of alcohol and other substances, in response to lights or noises, and when the individual is experiencing stress. Parasomnias appear to have a genetic component, although having a genetic predisposition toward parasomnias does not necessarily mean that the individual will develop a parasomnia.

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How is Non-Rapid Eye Movement Sleep Arousal Disorder Treated?

Few controlled trials have investigated treatments for NREM sleep arousal disorders and no published guidelines are available.

However, clinical research suggests that the following treatments have shown some promise for reducing the occurrence of one or more parasomnias:

  • Benzodiazepines, specifically diazepam and clonazepam, have shown promise in very small clinical trials and several case series. Triazolam and flurazepam have also been reported to be used with success.
  • Continuous positive airway pressure (CPAP) showed promise for individuals with somnambulism and disordered breathing in an open trial.
  • Antidepressant medications, specifically paroxetine and imipramine, have shown some benefit in case studies.
  • Hypnosis has shown some positive effects in several case series.

You can learn more about treatments for NREM sleep arousal disorders here.