Tobacco use disorder is grouped within the cluster of diagnoses called the substance-related and addictive disorders. Substance-related addictive disorders are characterized by a maladaptive pattern of substance use manifested by recurrent and significant adverse consequences related to the use of substances. These problems are persistent and occur repeatedly within the same 12-month period.

The term substance can refer to a drug, a medication, or a toxin. In addition to alcohol, types of substances to which individuals may become addicted include:
Substance-related disorders are divided into two groups:
The essential feature of a substance use disorder is a cluster of cognitive, behavioral, and physiological symptoms indicating that the individual continues using the substance despite significant substance-related problems. An important characteristic of this disorder is an underlying change in brain circuits that may persist beyond detoxification, particularly in individuals with severe disorders. The behavioral effects of these brain changes may be exhibited in the repeated relapses and intense drug craving when the individuals are exposed to drug-related stimuli.

The diagnosis of tobacco use disorder is assigned to children and adolescents who are dependent on the drug nicotine, due to use of tobacco products.
Tobacco use disorder is a problematic pattern of tobacco use leading to clinically significant impairment or distress, as manifested by at least two of the following, occurring within a 12-month period:
When we consider substance use disorder, we often think of substance dependence. Individuals are considered dependent on a substance when symptoms of tolerance and withdrawal are present:
Withdrawal is the development of substance-specific maladaptive behavioral changes, with physiological and cognitive concomitants, that is due to the cessation or reduction of substance use.

According to the National Survey on Drug Use and Health, more than 80 percent of smokers begin smoking before age 18, and more than 90 percent do so before leaving their teens. The DSM-5 notes that many people in the United States experiment with cigarettes in their teens, and the American Psychiatric Association estimates that about 20 percent of individuals will use tobacco at least monthly by age 18.
Cigarettes are the most commonly used tobacco product in the United States. The rewarding properties of cigarettes (e.g. behavioral reinforcement of the hand- to -to mouth habit) and societal approval of tobacco products (as featured in the media) enhance the addictive properties of nicotine. Additionally, lack of social support to cease smoking (i.e. due to cultural acceptance), and ease of access of tobacco products, make smoking cessation especially difficult for adolescents and teens.
The American Psychiatric Association has found there is a genetic component to substance related disorders.
Cigarettes are the most commonly used tobacco product in the United States. The rewarding properties of cigarettes (e.g. behavioral reinforcement of the hand- to -to mouth habit) and societal approval of tobacco products (as featured in the media) enhance the addictive properties of nicotine. Additionally, lack of social support to cease smoking (i.e. due to cultural acceptance), and ease of access of tobacco products, make smoking cessation especially difficult for adolescents and teens.
The American Psychiatric Association has found there is a genetic component to substance related disorders.

Research additionally suggests that the following treatments are promising: