Premature Ejaculation in Adults

ICD-10 Code: F52.4

Premature ejaculation is part of a cluster of diagnoses called the sexual dysfunctions. Sexual dysfunctions are a group of psychiatric conditions that include:

  • Delayed Ejaculation
  • Erectile Disorder
  • Male Hypoactive Sexual Desire Disorder
  • Premature Ejaculation
  • Female Orgasmic Disorder
  • Female Sexual Interest/Arousal Disorder
  • Genito-Pelvic Pain/Penetration Disorder
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Sexual dysfunctions are characterized by a significant impairment in a person's ability to respond sexually or to experience sexual pleasure. This can refer to an inability to perform or reach an orgasm, painful sexual intercourse, a strong repulsion of sexual activity, or an exaggerated sexual response cycle or sexual interest. An individual may have several sexual dysfunctions at the same time.

Biology, Psychology, and Sexual Function

Several factors can disrupt sexual functioning. Medical conditions such as multiple sclerosis, spinal cord injury or other nerve damage, diabetes, endocrine (hormonal) disorders, and prostatitis can all lead to problems of sexual interest or sexual capacity. Certain medications, such as selective serotonin reuptake inhibitors (SSRIs), may have sexual side effects. Some age-related vascular, nerve-related, and hormonal changes can also adversely affect sexual functioning. It is important to note that when sexual dysfunctions can be primarily attributed to one or more of these biological factors, it should not be diagnosed as a psychiatric disorder, and treatment should target the underlying medical problem. However, in many cases, medical concerns can contribute to a sexual problem, though not necessarily be the primary cause of the problem. In such cases, a psychiatric diagnosis may be appropriate.

Other psychiatric disorders can adversely affect sexual function. As one example, Major Depressive Disorder may be characterized by decreased interest in all or almost all of one's usual activities. Sexual interest, therefore, may be diminished. In such cases, a separate diagnosis of a sexual dysfunction is not warranted. However, as was the case with medical conditions, other psychiatric disorders can contribute to a sexual problem, though not necessarily be the primary cause of the problem. In such cases, a diagnosis of a sexual dysfunction may be appropriate.

Several psychological issues, even in the absence of a diagnosable psychiatric disorder, can contribute to sexual dysfunction. Negative body image may lead to feelings of anxiety around sexuality, inhibiting desire or capacity. Performance anxiety may similarly lead to problems of sexual function. Stressors, such as work or family concerns, may preoccupy the individual, affecting sexual interest or performance. A history of sexual trauma or other negative historical events may create negative associations with sexuality, thus undermining function. In such cases, a diagnosis of a sexual dysfunction is usually warranted.

Relationship factors can also contribute to problems of sexual functioning. At a purely physical level, often an individual's sexual concerns stem not from a problem within the individual, but from a lack of appropriate sexual stimulation from his or her partner. At an interpersonal level, some couples suffer from poor sexual communication, have poor understanding of sexuality, have different desires or preferences for sexual activity, or feel negatively about each other. All of these factors have the potential to adversely affect sexual arousal or performance. Such cases should not be diagnosed as a psychiatric disorder. Again, however, relationship problems can contribute to a sexual problem, though not necessarily be the primary cause of the problem. In such cases, a diagnosis of a sexual dysfunction may be appropriate.

The etiology of a sexual dysfunction is frequently unclear, and clinical judgment is needed. Often, multiple possible explanations need to be explored, using both medical and psychiatric examination procedures.

Sexuality is a complex process, coordinated by the neurologic, vascular and endocrine systems. Individually, sexuality incorporates family, societal and religious beliefs, and is altered with aging, health status and personal experience. In addition, sexual activity incorporates interpersonal relationships, each partner bringing unique attitudes, needs and responses into the coupling. All of these contribute to an individual's sexuality in varying degrees at any point in time as well as developing and changing throughout the life cycle. A breakdown in any of these areas may lead to sexual dysfunction.

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What is Premature Ejaculation?

Premature ejaculation is a psychiatric disorder that affects 1-3% of men. Premature ejaculation is characterized by consistently ejaculating within one minute of vaginal penetration and before the individual desires it.

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Although the definition is categorically heteronormative, the durational definition of one minute can be applied to males of varying sexual orientations and across sexual activities.

There are five factors that should be taken into consideration during the assessment and diagnosis of premature ejaculation:

  • Partner's sexual history and health status
  • Relationship quality such as ability to effectively communication, differences in sexual activity preference)
  • Individual factors such as body image, history of physical or sexual abuse, psychiatric comorbidity, life stressors
  • Cultural and religious background such as rules and attitudes towards sexual activity and sexuality
  • Medical background and treatment
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Understanding Premature Ejaculation

Premature ejaculation typically starts during a male's first sexual experience and persists thereafter. Some men may experience premature ejaculation early on, but gain ejaculatory control over time. Other males with premature ejaculation will experience lifelong symptoms.

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Many men report a sense of a lack of control over ejaculation and report anxiety about anticipating their inability to delay ejaculation in future sexual encounters. Males with premature ejaculation may have low self-esteem or self-confidence, a decreased sense of masculinity, and may experience depressed affect. They may avoid sexual encounters for fear of sexual dysfunction. This avoidance of sexual encounters may interfere with the ability to develop intimate relationships. Their partners commonly report reduced sexual satisfaction and reduced sexual desire. Thus, this disorder can produce both individual and interpersonal distress.

Premature ejaculation is commonly found in men with anxiety disorders, especially social anxiety disorder. It is frequently comorbid with erectile problems. The disorder has a genetic component, although having a genetic predisposition to premature ejaculation does not necessarily mean that someone will develop premature ejaculation.

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How is premature ejaculation treated?

Premature ejaculation is treatable. Published treatment guidelines for premature ejaculation include those from the American Urological Association and the International Society for Sexual Medicine.

First Line Treatments

  • Antidepressants, which are known to cause anorgasmia and delayed ejaculation. First line medications include:

  • Clomipramine

  • Dapoxetine

  • Fluoxetine

  • Paroxetine

  • Sertraline

  • Topical Therapies, which can be applied to the penis prior to intercourse to delay ejaculation. Topical anesthetics include:

  • Lidocaine/prilocaine cream

Second Line Treatments

In cases of nonresponse to first-line treatment, alternative treatments with reasonable evidence of efficacy include:

  • Behavioral therapies, which can address the anxiety, stress, worry, and other causes of premature ejaculation. Interventions can include helping men develop sexual skills that enable them to delay ejaculation, improve sexual communication, increase sexual self-confidence and decrease performance anxiety.

Third Line Treatments

When patients do not respond adequately to the first- and second-line treatments described above, other strategies might include:

  • Intracavernosal injections of alprostadil

  • PDE-5 inhibitors, which are medications that enable the penis to fill with blood by blocking the PDE5 enzyme. Specific medications include:

  • Sildenafil
  • Tadalafil
  • Vardenafil

Additional Treatments to Consider

Preliminary evidence suggests that the following strategies, while not a substitute for the more well-validated treatments described above, might be considered.

  • Acupuncture
  • Modafinil
  • Injection of botilunim toxin A into the bulbospongiosus muscle